Mechanism of albendozole action as a part of the drug is disruption
of carbohydrate metabolism in helminthes, which leads to its destruction and withdrawal from the animal body.
After oral administration albendozole is rapidly absorbed by gastrointestinal tract and penetrated into organs and tissues; it is mainly eliminated from the body with urine and faeces. Due to its egg-killing action it reduces pasture infestation by helminthes.
Mechanism of the closantel action is inhibition of oxidation phosphorylation in parasites.
Specific drug action is stimulation of ATF-enzyme which leads to disruption of phosphorylation process and electron transport, thus changing metabolism energy of parasite and leading to its death.
Albendazole and closantel included in the drug having synergistic effect, cause death to internal parasites and external parasites of ruminants, including trematodes, nematodes, cestodes and those resistant to benzimidazole, as well as gadfly larvae and sarcoproid mites.
By toxicity to warm-blooded animal the drug belongs to the Hazard Category 4 - «low risk drugs». The drug does not have teratogenic, embryo toxic, mutagenic and allergenic properties in therapeutic dose.