ENROFLOKSATSIN – 100

Enrofloxacin as a drug component belongs to the fluoroquinolones group. Mechanism of the enrofloxacin action on bacterial cells based on inhibiting apple acid biosynthesis. It causes morphological changes and destruction of pathogenic microorganisms. The drug is characterized by quick absorption and achieving high concentrations in blood serum.

The drug has a broad spectrum of antibacterial action against Gram-positive bacteria (staphylococci, streptococci, Corynebacterium, Clostridium and Listeria), Gram-negative bacteria (E. coli, Salmonella, Klebsiella, Proteus, Yersinia, Haemophilus influenzae bacteria, Pasteurella, actinobacillus, Pseudomonas, Bordetella, Brucella, Campylobacter) and mycoplasmas.

Enrofloxacin is quickly absorbed from the injection site and penetrates into all tissues and organs of the body. Maximum concentration of the drug in blood is achieved through 0.5-1 hour after administration and retains for 4-6 hours, and therapeutic concentration - for 24 hours.

The drug doesn’t undergo biotransformation in the body and is eliminated mainly unchanged with urine and bile.

The drug is administered intramuscularly once a day.

Cattle, ruminants, pigs a daily dose is based on 0,5-1ml of the drug per 20 kg of animal weight (2,5 – 5 mg enrofloksatsin per 1 kg). Treatment is 3-5 days, depending on the disease severity.

Fur-bearing animals (mink, fox, Arctic fox), dogs a daily dose is based on 0,5 ml of the drug (5mg enrofloksatsin) per 10 kg of animal weight. The course of treatment is 3-5 days depending on the disease severity.

Half dose is administered within 3-5 days for prevention treatment.

To avoid possible pain reaction the drug should be administered in amount not more than 2-3 ml in one place to large animal and not more than 1 ml – to small animals.

The drug is prescribed for prevention and treatment of the following diseases in farm animals and poultry:

Cattle and ruminants: enteritis, respiratory infections, colibacillosis, pasteurellosis, salmonellosis, mycoplasmosis, clostridioz, dysentery, leptospirosis;

Pigs: bacterial diseases of gastrointestinal tract (kolidiareya, koliseptitsemiya) and bacterial respiratory diseases;

Rabbits: pasteurellosis, enterotoxemia, enteritis, dysentery, respiratory infections, listeriosis, endometritis, runny nose, rodentioz etc.;

Fur-bearing animals (mink, fox, Arctic fox), dogs: bacterial disease of gastrointestinal tract and respiratory tract, leptospirosis.

Enrofloksatsin injection in pigs sometimes causes local irritation. During treatment occasionally indigestion can be observed in calves and pigs. Application of enrofloksatsin drug may cause changes in articular cartilages in dogs of small and medium species aged 2 to 8 months and in large, slow-growing species - up to 18 months.

CONTRAINDICATIONS: The drug should not be applied to horses, pregnant female dogs and breeding pigs as well as to female dogs in lactation. It is restricted to apply this drug to cats under 8 months, dogs less than 12 months and large dog species - up to 18 months.

It is not allowed to use Enrofloksatsin-50 in milking animals.

SPECIFIC INSTRUCTIONS: This drug should not be used simultaneously with tetracyclines, macrolides and chloramphenicol.