Enrofloxacin affects DNA gyrase, which inhibits apple acid biosynthesis in microorganisms. Enrofloxacin belonging to the fluoroquinolones group affects DNA gyrase, which inhibits apple acid biosynthesis in microorganisms, causing morphological changes in it and death. This particular mechanism of action eliminates possibility of the resistance growth with participation of plasmids which is caused by antibiotics and chemotherapeutic agents of previous generations.
Antibacterial effect of enrofloxacin has been detected against Gram-positive (Staphylococcus, Streptococcus, Corynebacterium, Clostridium and Listeria monocytogenes) and Gram-negative bacteria (E. coli, Salmonella, Klebsiella, Proteus, Yersinia, Haemophilus influenzae bacteria, Pasteurella, actinobacillus, Pseudomonas, Bordetella, Brucella, Campylobacter) and mycoplasmas.