Enrofloxacin affects DNA gyrase, which inhibits apple acid biosynthesis in microorganisms. Antibacterial effect of enrofloxacin has been detected against Gram-positive (Staphylococcus, Streptococcus, Corynebacterium, Clostridium and Listeria monocytogenes) and Gram-negative bacteria (E. coli, Salmonella, Klebsiella, Proteus, Yersinia, Haemophilus influenzae bacteria, Pasteurella,
actinobacillus, Pseudomonas, Bordetella, Brucella, Campylobacter) and mycoplasmas.
Enrofloxacin is well and quickly absorbed by gastrointestinal tract and penetrates into all tissues and organs of the body. Maximum concentration in blood is achieved 0.5-1 h after administration and retains for 4-6 hours and therapeutic concentration - for 24 hours.
The drug doesn’t undergo biotransformation in the body and is eliminated mainly unchanged with urine and bile.