IMISAN

Imisan is a drug as solution for injection used for treatment and prevention of blood protozoan diseases in cattle and ruminants, horses and dogs.

Imisan as an active substance contains 120 mg imidokarb dipropionate in 1 ml. Imisan is a yellow solution for injection.

Imisan is prepackaged by 10, 20, 50,100 ml in dark glass vials or bottles with suitable capacity, sealed with rubber stoppers and covered by aluminum caps. Imisan should be stored with caution (see list B) in a dry, dark place within the temperature range +2°C to +25° C.

Shelf life is 2 years from the date of manufacture if stored under specified storage conditions.

Category:

Active ingredient is imidokarb dipropionate active against pathogens of babesiosis, nuttalliosis, anaplasmosis. Mechanism of action is based on inhibition of polyamines metabolism in blood parasites.

After parenteral administration therapeutic concentration of imidokarb dipropionate in blood shall be achieved in 18-24 hours and retained in blood at the piroplazmastatic level within 4-6 weeks.

Imidokarb dipropionate is accumulated mainly in liver and kidneys; it is eliminated primarily with urine unchanged. Imisan is a low-hazardous substance according to the impact degree on body.

Imisan is administered in animals intramuscularly in the neck area (cattle, horses and sheep) or subcutaneously in the neck area (dogs) with observance of aseptic and antiseptic rules in the following doses:

Species  Imisan dosage 
Babesiosis  Anaplasmosis Mixed invasion 
For treatment purpose 
Cattle  2,0 ml per 100 kg 2,5 ml per 100 kg 2,5 ml per 100 kg
Ruminants  0,2 ml per 10 kg - -
Horses, donkeys, mules 2,0 ml per 100 kg - -
Dogs 0,25-0,5 ml per 10 kg - -
For preventive purpose
Cattle - - 2,5 ml per 100 kg
Horses, donkeys, mules 2,0 ml per 100 kg - -
Dogs 0,5 ml per 10 kg - -

In order to eliminate pathogens and B.caballi in horses, donkeys and mules the treatment is carried out as follows:

Species  Dosage, ml/100 kg of animal weight 
B.caballi B.equi
Horses  By 2 ml twice with 24 hour interval  By 2 ml four times with 72 hour interval
Donkeys and mules  By 2 ml twice with 24 hour interval -

Imisan with medical purpose is used in animals with clinical signs of disease. Sick animals are left in quiet and in addition symptomatic drugs are prescribed depending on physiological conditions.

Imisan is used for treatment and prevention of blood protozoan diseases (babesiosis, nuttaliosis, anaplasmosis and mixed invasions) in cattle and ruminants, horses and dogs.

Any side effects and complications shall not be observed in animals if Imisan is administered in accordance with recommended doses according to these instructions. In rare cases, there may be local reaction in the form of hyperemia or painful swelling in the injection site, which disappears after 1-2 days.

Repeated administration may be accompanied by decrease in blood pressure, and during drug overdose bradycardia, frequent and irregular breathing, anorexia, tremor may be observed.

When animal has individual hypersensitivity to the drug possible signs of complications (depression, anxiety, excessive salivation, lacrymation, sweating, muscle tremors, frequent urination and defecation) may be observed, in such cases 1% solution of atropine shall be administered subcutaneously.

Intoxication may be developed during mass death of blood parasites and destruction of red blood cells in animals. In such cases intensive care should be conducted including intravenous infusion of electrolytic solutions and symptomatic treatment.

CONTRAINDICATIONS: This drug is not administered subcutaneously or intravenously (except for dogs). Do not use the drug for 4 weeks after vaccination with a live vaccine against babesiosis and anaplasmosis. It is restricted to use simultaneously with organochlorine and organophosphorus compounds and cholinesterase inhibitors as well.

Slaughter of cattle and sheep for meat shall be allowed not earlier than 45 days after the last Imisan administration; meat of animals during urgent slaughter before expiry of specified period can be used for production of meat and bone tankage.

Milk of dairy cows may be used for food no earlier than 7 days after the last drug administration. Before expiry of this term the milk after boiling shall be used for animal feed. Milk of dairy sheep treated by Imisan shall not be used for food purposes during entire period of lactation.

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