Ketoprofen as an ingredient of the drug is effective for treatment of acute, subacute and chronic inflammations accompanied by pain symptoms.
Mechanism of the ketoprofen action is in inhibition of the prostaglandins synthesis (cyclooxygenase- 2 and partially cyclo-oxygenase-1) by disruption of the arachidonic acid metabolism. In therapeutic doses ketoprofen ensures anti-inflammatory, analgesic, antipyretic and antiendotoxic effect.
After intramuscular administration of the drug maximum concentration of ketoprofen shall be observed in blood plasma after 30 minutes. Bioavailability of ketoprofen ranges between 85% and 100% depending on species. Ketoprofen is eliminated from the body mainly through kidneys.
In compliance with GOST 12.1.007-76 according to the impact degree on body Ketoprofol 1% and 10% refers to Hazard Category 4 (low- hazard substance); its does not have sensitizing effect in the body at recommended doses