Mechanism of closantel action is inhibition of oxidation phosphorylation in parasites. Specific drug action is stimulation of ATF-enzyme, which leads to disruption of the phosphorylation process and electron transport changing of the parasite energy metabolism so that it leads to its death.
During parenteral administration the drug is quickly absorbed at the injection site and penetrated into organs and tissues of animals.
Maximum drug concentration in blood shall be achieved 12 hours after drug administration and retained for 24-36 hours. Therapeutic concentration of the drug in the animal body shall retain for 10-11 days.
Closantel is practically unaffected by biotransformation in the body and is eliminated mainly unchanged.