Makroprim Concentrate is a combined antimicrobial drug; it has bactericidal effect against Gram-negative (E. coli, Klebsiella spp., Salmonella spp., Proteus spp., Campylobacter spp., Pseudomonasaeruginosa, Bordetella spp., Pasteurella spp., Haemophilus spp., Actinobacillus spp., Brucella spp.) and gram-positive bacteria (Staphylococcus spp., Streptococcus spp., Listeriamonocytogenes, Erysipelothrix suis), mycoplasma, chlamydia, eimeria. Viruses and fungi are not
sensitive to the drug.
Unique drug formula ensures a broad spectrum of activity against mycoplasmal, bacterial and mixed infection diseases.
Tylosin combined with 50S ribosomal subunit of susceptible organisms blocks ribosome binding point with tRNA (peptidyl-tRNA) that interrupts attachment of amino acids and growth of the peptide chain.
Sulfamerazine trimethoprim disrupts synthesis of purine and pyrimidine nucleotides by blocking synthesis of dihydrofolic acid. Colistin blocks phospholipid components of cytoplasmic membrane and disrupts its structure
and cause bacteriolysis.
Active ingredients of the drug except for colistin sulfate are well absorbed by gastrointestinal tract and penetrate into all organs and tissues. Therapeutic concentration is retained within 12 hours. The drug is eliminated from the body with urine and faeces.